Repurposing vaccine-induced anti-HBV antibodies for endogenous immunotherapy against EGFR-positive tumors

Zijiang Zhang; Yanchun Li; Haofei Hong; Zhimeng Wu

doi:10.1039/D5CC03243A

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Repurposing vaccine-induced anti-HBV antibodies for endogenous immunotherapy against EGFR-positive tumors

Zijiang Zhang,^a Yanchun Li,^a Haofei Hong^a and Zhimeng Wu

*^a

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* Corresponding authors

^a The Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
E-mail: zwu@jiangnan.edu.cn
Fax: +86-510-85197582
Tel: +86-510-85197582

Abstract

A nanobody chimera composed of an EGFR-targeting nanobody and the LOOP1 peptide derived from HBV surface antigen is capable of harnessing HBV vaccine-induced immunity for cancer immunotherapy.

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DOI: https://doi.org/10.1039/D5CC03243A
Article type: Communication
Submitted: 09 Jun 2025
Accepted: 20 Aug 2025
First published: 27 Aug 2025

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Chem. Commun., 2025, Advance Article

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Repurposing vaccine-induced anti-HBV antibodies for endogenous immunotherapy against EGFR-positive tumors

Z. Zhang, Y. Li, H. Hong and Z. Wu, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03243A

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Chemical Communications

Repurposing vaccine-induced anti-HBV antibodies for endogenous immunotherapy against EGFR-positive tumors

Abstract

Supplementary files

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Repurposing vaccine-induced anti-HBV antibodies for endogenous immunotherapy against EGFR-positive tumors

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