A Pd nanoparticle-loaded nanoscale covalent organic framework to enhance tumor therapy by synergistic hydrogen/photothermal therapy

Abstract

Herein, we report a nanoscale composite COF material loaded with Pd nanoenzyme and H2 via a stepwise post-synthetic modification. The obtained PdH2@COF has been shown to affect mitochondrial function by disrupting the intracellular redox balance and thus down-regulated the expression of heat shock protein (HSP), thereby enhancing photothermal therapy of tumor.