A lysosomal fluorescent probe for the imaging of viscosity in tumoral ferroptosis and rheumatoid arthritis mice models

Abstract

Viscosity, as an important micro-environment parameter, is closely related to the occurrence and progression of various diseases. Herein, we have developed a novel fluorescent probe (BIB) for lysosomal viscosity detection. Interestingly, using BIB, in vivo imaging of viscosity fluctuations in tumoral ferroptosis and rheumatoid arthritis models has been successfully achieved.