SABRE-SHEATH hyperpolarized 15N2-imidazole for Zn2+ sensing

Abstract

Zinc ions are essential for numerous biological functions and activities. Accordingly, Zn2+ sensors are crucial in biomedical research to understand the role of Zn2+ in health and disease. Here, we demonstrated the viability of SABRE-SHEATH hyperpolarized 15N2-imidazole, providing an NMR signal enhancement of 45 700 fold (p = 2.15%), as a probe for Zn2+ sensing by monitoring the Zn-imidazole interaction using NMR and extracted a LOD of 1.3 mM. This study is one of the first demonstrations of SABRE-SHEATH hyperpolarized 15N as a sensor of other non-hyperpolarized species, which promises chemical sensing without penetration-depth limitations.

Graphical abstract: SABRE-SHEATH hyperpolarized 15N2-imidazole for Zn2+ sensing

Supplementary files

Article information

Article type
Communication
Submitted
22 May 2025
Accepted
19 Jun 2025
First published
04 Jul 2025
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2025, Advance Article

SABRE-SHEATH hyperpolarized 15N2-imidazole for Zn2+ sensing

B. K. S. Dhali, A. Abdurraheem, M. Abdulmojeed, A. Samoilenko, M. Pike, R. J. Harrison, F. Theiss, B. M. Goodson, E. Y. Chekmenev and T. Theis, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02890F

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