Palladium-catalysed carbonylation of aryl diazonium salts to access bioconjugation-ready esters†
Abstract
We report a palladium-catalyzed esterification protocol using aryl diazonium salts and N-hydroxysuccinimidyl (NHS) formate as a CO surrogate, avoiding the use of toxic CO gas. This mild and efficient method employs readily available starting materials and affords NHS esters suitable for late-stage functionalization and bioconjugation applications.