Palladium-catalysed carbonylation of aryl diazonium salts to access bioconjugation-ready esters

Abstract

We report a palladium-catalyzed esterification protocol using aryl diazonium salts and N-hydroxysuccinimidyl (NHS) formate as a CO surrogate, avoiding the use of toxic CO gas. This mild and efficient method employs readily available starting materials and affords NHS esters suitable for late-stage functionalization and bioconjugation applications.

Graphical abstract: Palladium-catalysed carbonylation of aryl diazonium salts to access bioconjugation-ready esters

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Article information

Article type
Communication
Submitted
14 May 2025
Accepted
12 Jun 2025
First published
18 Jun 2025

Chem. Commun., 2025, Advance Article

Palladium-catalysed carbonylation of aryl diazonium salts to access bioconjugation-ready esters

P. Paul and J. Dash, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02739J

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