Iron–anthraquinone cooperative catalysis enables mild C–C bond cleavage of cyclohexanones via oxygen-centered radicals

Shichang Li; Zongyi Yu; Liyuan Duan; Cunfei Ma; Jingnan Zhao; Huinan Sun; Guofeng Zhao; Peiyu Yi; Qilei Liu; Qingwei Meng

doi:10.1039/D5CC02725J

Iron–anthraquinone cooperative catalysis enables mild C–C bond cleavage of cyclohexanones via oxygen-centered radicals

Shichang Li,^a Zongyi Yu,^a Liyuan Duan,^a Cunfei Ma,^a Jingnan Zhao,^a Huinan Sun,^a Guofeng Zhao,^a Peiyu Yi,^a Qilei Liu

*^a and Qingwei Meng

*^ab

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* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China
E-mail: Mengqw@dlut.edu.cn

^b Ningbo Institute of Dalian University of Technology, No. 26 Yucai Road, Jiangbei District, Ningbo, China

Abstract

This study introduces an Fe/anthraquinone dual catalytic system for oxidative cleavage of non-strained cyclohexanones to mono-carboxylic acids under mild visible-light conditions (0 °C). Efficient activation of inert C–C bonds via oxygen-centered radical-mediated cleavage is achieved, providing a sustainable approach to valorize bulk chemicals and synthesize pharmaceutical intermediates.

Chemical Communications

Iron–anthraquinone cooperative catalysis enables mild C–C bond cleavage of cyclohexanones via oxygen-centered radicals

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Iron–anthraquinone cooperative catalysis enables mild C–C bond cleavage of cyclohexanones via oxygen-centered radicals

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