A clickable spherical nucleic acid probe for fluorescence and synchrotron radiation X-ray dual-modality imaging

Xiaobo Wang; Xin Yan; Feng Zhou; Qiaowei Tang; Zijian Xu; Jichao Zhang; Yong Guan; Yanhong Sun; Ying Zhu; Jun Hu; Xiaoqing Cai

doi:10.1039/D5CC02645H

A clickable spherical nucleic acid probe for fluorescence and synchrotron radiation X-ray dual-modality imaging†

Xiaobo Wang,^af Xin Yan,^af Feng Zhou,^af Qiaowei Tang,^d Zijian Xu,^b Jichao Zhang,^b Yong Guan,^e Yanhong Sun,^c Ying Zhu,

^c Jun Hu^abc and Xiaoqing Cai

*^abf

Author affiliations

* Corresponding authors

^a Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Key Laboratory of Micro Interface Physics and Detection, Chinese Academy of Sciences, Shanghai 201800, China
E-mail: wangxiaobo@sinap.ac.cn, yanxin@sinap.ac.cn, zhoufeng@sinap.ac.cn

^b Shanghai Synchrotron Radiation Facility (SSRF), Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China
E-mail: xuzj@sari.ac.cn, zhangjc@sari.ac.cn, caixq@sari.ac.cn

^c Institute of Materials Biology, Department of Chemistry, School of Science, Shanghai University, Shanghai 200444, China
E-mail: sunyanhong@shu.edu.cn, zhuying331@shu.edu.cn, hujun64@shu.edu.cn

^d Xiangfu Laboratory, Jiaxing 314102, China
E-mail: tangqw_sinap@163.com

^e University of Science and Technology of China, National Synchrotron Radiation Laboratory, Hefei 230029, China
E-mail: yongg@ustc.edu.cn

^f University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

In this study, we have developed a dual-mode probe based on click chemistry for spherical nucleic acids (SNAs), achieving extremely specific fluorescence imaging and synchrotron X-ray microscopy of neuronal cells.

Chemical Communications

A clickable spherical nucleic acid probe for fluorescence and synchrotron radiation X-ray dual-modality imaging†

Abstract

Supplementary files

Transparent peer review

Article information

Download Citation

Permissions

A clickable spherical nucleic acid probe for fluorescence and synchrotron radiation X-ray dual-modality imaging

Social activity

Search articles by author

Spotlight

Advertisements