Direct N-methyl C–H esterification of O-tosyl hydroxamates to enable facile synthesis of hemiaminal esters

Abstract

Here we present a new method for synthesizing amide hemiaminal esters through the direct N-methyl C–H esterification of O-tosyl hydroxamates. This approach demonstrates good tolerance for a variety of functional groups and operates under mild, transition-metal-free conditions, thus providing an accessible and effective pathway to hemiaminal esters.