From the journal:

Chemical Communications

Developing a Zn(ii)-metallovesicle for loading and delivering doxorubicin to kill cancer cells—a multi-drug delivery system

Abhishek Dutta,a   Subhajit Ghosha  and  Parthasarathi Dastidar ORCID logo *a  

* Corresponding authors

a School of Chemical Science, Indian Association for the Cultivation of Science (IACS), 2a, 2b Raja S. C. Mullick Road, Kolkata 700032, West Bengal, India
E-mail: ocpd@iacs.res.in, ocpdastidar@gmail.com

Abstract

An amphiphilic Zn(II)-coordination polymer (CP3) was rationally designed, successfully synthesised, and crystallographically characterized. It was derived from the non-steroidal anti-inflammatory drug (NSAID) flurbiprofen, as well as isophthalic acid and Zn(NO3)2. CP3 was loaded with the anti-cancer drug doxorubicin, which was delivered to multicellular spheroids of the HeLa cancer cells, thereby making it suitable for developing a multi-drug delivery system.

Graphical abstract: Developing a Zn(ii)-metallovesicle for loading and delivering doxorubicin to kill cancer cells—a multi-drug delivery system

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Article information

DOI
https://doi.org/10.1039/D5CC02372F
Article type
Communication
Submitted
28 Apr 2025
Accepted
26 Aug 2025
First published
09 Sep 2025

Chem. Commun., 2025, Advance Article

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Developing a Zn(II)-metallovesicle for loading and delivering doxorubicin to kill cancer cells—a multi-drug delivery system

A. Dutta, S. Ghosh and P. Dastidar, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02372F

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