From the journal:

Chemical Communications

Electrochemical hydrotrifluoromethylation of alkynes†

Jihoon Janga  and  Eun Jin Cho ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Chung-Ang University, 84, Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
E-mail: ejcho@cau.ac.kr

Abstract

We report the electrochemical hydrotrifluoromethylation of alkynes using the Langlois reagent as a CF3 source. The mild conditions enable broad functional group tolerance and allow late-stage functionalization. Mechanistic studies reveal that DMSO serves a dual role as both solvent and hydrogen atom donor.

Graphical abstract: Electrochemical hydrotrifluoromethylation of alkynes

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D5CC02370J
Article type
Communication
Submitted
28 Apr 2025
Accepted
30 Jun 2025
First published
01 Jul 2025

Chem. Commun., 2025, Advance Article

Permissions

Request permissions

Electrochemical hydrotrifluoromethylation of alkynes

J. Jang and E. J. Cho, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02370J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements