Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation†
Abstract
S-Fluoroacetylation of cysteine residues enables efficient cleavage of main-chain amide bonds in peptides and proteins under neutral aqueous conditions.
* Corresponding authors
a
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
E-mail:
ojida@phar.kyushu-u.ac.jp
S-Fluoroacetylation of cysteine residues enables efficient cleavage of main-chain amide bonds in peptides and proteins under neutral aqueous conditions.
Y. Matsumoto, N. Zenmyo, S. Watanabe, K. Sasaki-Tabata, S. Uchinomiya, N. Shindo and A. Ojida, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02215K
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