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Chemical Communications

Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation†

Yuya Matsumoto, ORCID logo a   Naoki Zenmyo,a   Shunsuke Watanabe,a   Kaori Sasaki-Tabata,a   Shohei Uchinomiya,a   Naoya Shindo ORCID logo a  and  Akio Ojida ORCID logo *a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
E-mail: ojida@phar.kyushu-u.ac.jp

Abstract

S-Fluoroacetylation of cysteine residues enables efficient cleavage of main-chain amide bonds in peptides and proteins under neutral aqueous conditions.

Graphical abstract: Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation

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Article information

DOI
https://doi.org/10.1039/D5CC02215K
Article type
Communication
Submitted
08 May 2025
Accepted
23 Jun 2025
First published
02 Jul 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025, Advance Article

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Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation

Y. Matsumoto, N. Zenmyo, S. Watanabe, K. Sasaki-Tabata, S. Uchinomiya, N. Shindo and A. Ojida, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02215K

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