Cascade heteroarylation/annulation of arylphosphonic acid monoesters with benzothiophenes: access to benzothieno-fused oxaphosphacycles

Abstract

Sequential C-H/C-H and C-H/O-H cross-dehydrogenative coupling of arylphosphonic acid monoesters with benzothiophenes has been achieved to afford benzothieno-fused oxaphosphacycles under the Ru(II)-catalysis. This strategy can be extended to the cross-coupling of vinylphosphonic acid monoesters. The site-selectivity, substrate scope, functional group tolerance and photophysical properties are the important features.