Oxidative [3+2] annulation of activated pyridines for the synthesis of indolizinyl sulfonyl fluorides: a class of important pharmacophores

Abstract

A novel method for synthesizing valuable indolizine-functionalized sulfonyl fluorides has been developed through oxidative [3+2] annulation of activated pyridines and β-arylethenesulfonyl fluorides. This transformation features high efficiency, mild reaction conditions and readily accessible starting materials, and is transition-metal free. Consequently, this reaction holds significant promise in the field of medicinal chemistry and other related disciplines.