Colorimetric ALP detection with a ligand-exchanged Au8 cluster

Jingjing Yang; Qing You; Qian Wang; Hongliang Zhao; Yu Cheng; Ming Yao; Junchi Ruan; Yan Zhao; Man-Bo Li; Zhikun Wu

doi:10.1039/D5CC02136G

Colorimetric ALP detection with a ligand-exchanged Au₈ cluster†

Jingjing Yang,‡^a Qing You,‡^b Qian Wang,‡^a Hongliang Zhao,^a Yu Cheng,^a Ming Yao,^a Junchi Ruan,^a Yan Zhao,*^a Man-Bo Li

*^a and Zhikun Wu

*^ab

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* Corresponding authors

^a Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, China
E-mail: 20231@ahu.edu.cn, mbli@ahu.edu.cn

^b Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, CAS Center for Excellence in Nanoscience, Institute of Solid State Physics, Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Sciences, Hefei, Anhui 230601, China
E-mail: zkwu@issp.ac.cn

Abstract

An atomically precise Au₈ nanocluster (dppm/dppp) synthesized via ligand exchange exhibits oxidase-like activity. Alkaline phosphatase (ALP) quenches O₂˙⁻, enabling sensitive and specific colorimetric detection and demonstrating diagnostic potential.

This article is part of the themed collection: 2025 Pioneering Investigators

Chemical Communications

Colorimetric ALP detection with a ligand-exchanged Au₈ cluster†

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Colorimetric ALP detection with a ligand-exchanged Au₈ cluster

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Chemical Communications