Issue 59, 2025
From the journal:

Chemical Communications

Electrochemical S-vinylation of sulfinamides with β-bromostyrenes†

Yaseen Hussain,a   Ivan Sliusarevskyi,a   Claire Empel,ac   Magnus Rueping ORCID logo *b  and  Rene M. Koenigs ORCID logo *ac  

* Corresponding authors

a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany

b KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
E-mail: magnus.rueping@kaust.edu.sa

c Department of Chemistry, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany
E-mail: rene.koenigs@uni-bayreuth.de

Abstract

We present an electrochemical method for sulfoximine synthesis via radical cross-coupling of sulfonimidoyl and styryl radicals, generated from sulfinamides and bromostyrenes. This approach enables the efficient synthesis of vinyl sulfoximines, including bioactive-tethered derivatives, in moderate to good yields.

Graphical abstract: Electrochemical S-vinylation of sulfinamides with β-bromostyrenes

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Article information

DOI
https://doi.org/10.1039/D5CC02045J
Article type
Communication
Submitted
11 Apr 2025
Accepted
30 May 2025
First published
06 Jun 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025,61, 11017-11020

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Electrochemical S-vinylation of sulfinamides with β-bromostyrenes

Y. Hussain, I. Sliusarevskyi, C. Empel, M. Rueping and R. M. Koenigs, Chem. Commun., 2025, 61, 11017 DOI: 10.1039/D5CC02045J

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