Light-switchable divergent C–H activation and cross-coupling of cyclic ethers with aromatic aldehydes

Abstract

Divergent coupling reactions of cyclic ethers provide a powerful strategy for accessing high-value small molecules. We report a metal-free, light-regulated divergent method for C–H functionalization of cyclic ethers with aromatic aldehydes that selectively yields either hydroxyarylation or cross-dehydrogenative coupling products. Using tert-butyl peroxybenzoate as an oxidant and cyclic ether as both the solvent and the reductant, the reaction proceeds via a condition-dependent radical/ionic mechanism. This strategy enables sustainable access to diverse cyclic ether derivatives for medicinal and materials applications.

Graphical abstract: Light-switchable divergent C–H activation and cross-coupling of cyclic ethers with aromatic aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
10 Apr 2025
Accepted
23 Jun 2025
First published
24 Jun 2025

Chem. Commun., 2025, Advance Article

Light-switchable divergent C–H activation and cross-coupling of cyclic ethers with aromatic aldehydes

X. Yang, Q. Mou and M. Liu, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02025E

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