Electrochemical site-selective C(sp3)–H amination of alkyl substituted indoles and pyrroles

Shuai Liu; Yongqi Ge; Jianan Li; Xiaoyu Sheng; Tian-Shu Zhang; Qiong Wu; Weijie Ding; Xu Cheng

doi:10.1039/D5CC02009C

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Electrochemical site-selective C(sp³)–H amination of alkyl substituted indoles and pyrroles†

Shuai Liu,

*^a Yongqi Ge,^a Jianan Li,^a Xiaoyu Sheng,^a Tian-Shu Zhang,^a Qiong Wu,

^a Weijie Ding*^b and Xu Cheng

*^c

Author affiliations

* Corresponding authors

^a School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou, China
E-mail: 12102@xzit.edu.cn

^b Department of Material Science and Technology, Taizhou University, Taizhou, China
E-mail: wding@tzc.edu.cn

^c Jiangsu Key Laboratory of Advanced Organic Materials, National Demonstration Center for Experimental Chemistry Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
E-mail: chengxu@nju.edu.cn

Abstract

Precise cleavage of a C(sp³)–H bond among multi-C(sp³)–H bonds with similar properties is highly valuable yet remains challenging. Herein, we develop an electrochemical site-selective C(sp³)–H amination of C2-methyl/ethyl indoles and pyrroles, achieving moderate-to-high yields without the need for external oxidants or metal catalysts. The reaction exhibits excellent regioselectivity and broad substrate compatibility.

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Article information

DOI: https://doi.org/10.1039/D5CC02009C
Article type: Communication
Submitted: 11 Apr 2025
Accepted: 16 Jun 2025
First published: 16 Jun 2025

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Chem. Commun., 2025, Advance Article

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Electrochemical site-selective C(sp³)–H amination of alkyl substituted indoles and pyrroles

S. Liu, Y. Ge, J. Li, X. Sheng, T. Zhang, Q. Wu, W. Ding and X. Cheng, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02009C

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