Enabling ultra-specific lysosomal polarity fluorescence response via intramolecular π-π stacking-mediated conformational locking

Abstract

Designing ultra-specific polar fluorescent probes through the strategy of intramolecular π-π interactions was reported. Based on the strategy, a high-performance lysosomal polarity probe, named P-DOTPA, was developed. It exhibits high specificity, ultra-high sensitivity, near-infrared emission, and the ability to generate superoxide radicals (O2−•) under irritation.