Cu(ii)-catalyzed synthesis of 3-functionalized benzofurans via sequential nucleophilic cyclization and C–C bond activation

Abstract

A domino Cu-catalyzed nucleophilic cyclization and C–C bond activation to access various 3-acylated benzofurans has been developed. The in situ generated benzofuranylcopper intermediate was coupled with cyclopropenone, wherein the ring-opening of cyclopropenone with phenol was effectively suppressed. This strategy features excellent substrate scope, good functional group tolerance, and high atomic economy.