Modifications of terpenoids via inert aliphatic C–H bond heteroarylation with heteroarenes

Abstract

Here, we describe a method to modify commercially abundant terpenoids via inert aliphatic C–H bond heteroarylation directly with heteroarenes. The reaction is catalyzed by decatungstate anion under near-ultraviolet light irradiation. Furthermore, the inhibition effect of lipopolysaccharide (LPS)-induced nitric oxide (NO) production activity and cell proliferative inhibition in HUVEC and HCC1806 cells of the derivatives were evaluated. The heteroarylation could significantly result in changes in biological activity of terpenoids.