Photocatalytic oxidation of biologically relevant reducing agents by [Ru(bpy)3](PF6)2

Iman Doumi; Daniella Al Othman; Shao-An Hua; Vincent Lebrun; Franc Meyer; Peter Faller

doi:10.1039/D5CC01702E

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Photocatalytic oxidation of biologically relevant reducing agents by [Ru(bpy)₃](PF₆)₂†

Iman Doumi,

‡^a Daniella Al Othman,‡^a Shao-An Hua,^bc Vincent Lebrun,

^a Franc Meyer

^b and Peter Faller

*^a

Author affiliations

* Corresponding authors

^a Institut de Chimie (UMR 7177) University of Strasbourg – CNRS4 rue Blaise Pascal, 67000 Strasbourg, France
E-mail: pfaller@unistra.fr

^b Institute of Inorganic Chemistry, University of Göttingen, Tammannstrasse 4, D-37077 Göttingen, Germany

^c Department of Chemistry and Biochemistry, National Chung Cheng University, 168 University Rd., Min-Hsiung, Chiayi 62102, Taiwan

Abstract

Ru complexes are widely studied in photodynamic therapy. The type I mechanism of action is based on a photoinduced electron transfer from the complex to O₂ and needs an electron donor to be catalytic. Little is known about electron donors among physiologically relevant compounds. Hence, we investigated the oxidation of ascorbate, NADH, cysteine, and glutathione with the canonical [Ru(bpy)₃](PF₆)₂ as well as a derivative with a peripheral disulphide unit, [Ru(^S–Sbpy)(bpy)₂](PF₆)₂. The established reactivity order is ascorbate > NADH ∼ cysteine > glutathione.

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Article information

DOI: https://doi.org/10.1039/D5CC01702E
Article type: Communication
Submitted: 26 Mar 2025
Accepted: 22 Apr 2025
First published: 23 Apr 2025
This article is Open Access

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Chem. Commun., 2025, Advance Article

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Photocatalytic oxidation of biologically relevant reducing agents by [Ru(bpy)₃](PF₆)₂

I. Doumi, D. Al Othman, S. Hua, V. Lebrun, F. Meyer and P. Faller, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC01702E

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