From the journal:

Chemical Communications

A multi-functional synergistic platform of Cas12a split dsDNA activators†

Xiaolong Li,‡a   Jiarun Wang,‡a   Xianzhi Cheng,a   Qin Xu,*a   Lan She ORCID logo *b  and  Tongbo Wu ORCID logo *a  

* Corresponding authors

a School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
E-mail: xuqin19@hust.edu.cn, wutongbo@hust.edu.cn

b Department of Inorganic Chemistry, Naval Medical University, 325 Guohe Road, Shanghai, China
E-mail: slgs4100@126.com

Abstract

This work comprehensively explores the effects of various positions of Cas12a split activators. Based on this, a multi-functional synergistic platform was constructed. The construction of a structural dynamic network, the sensitive detection of APE1, and a time-controlled photo-activation have been achieved, demonstrating the potential for expanding Cas12a applications.

Graphical abstract: A multi-functional synergistic platform of Cas12a split dsDNA activators

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D5CC01613D
Article type
Communication
Submitted
21 Mar 2025
Accepted
02 Apr 2025
First published
07 Apr 2025

Chem. Commun., 2025, Advance Article

Permissions

Request permissions

A multi-functional synergistic platform of Cas12a split dsDNA activators

X. Li, J. Wang, X. Cheng, Q. Xu, L. She and T. Wu, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC01613D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements