An [(IPr)AuCl]-catalyzed formal [4+2] process of N-Ar N,O-acetals with arylacetylenes for the construction of pyrrolo[1,2-a]quinolines

Abstract

An efficient approach to access functionalized pyrrolo[1,2-a]quinolone skeletons was developed through [(IPr)AuCl]-catalyzed formal intermolecular [4+2] reaction of N-Ar N,O-acetals 6a–6h with arylacetylenes 7a–7r. As a result, a series of 3,3a-dihydropyrrolo[1,2-a]quinolin-1(2H)-one derivatives 8a–8o and 9a–9n were synthesized with excellent regioselectivity.