From the journal:

Chemical Communications

Harnessing the power of iridium AIEgens for NAD(P)H detection in aqueous medium and living cells†

Ajay Gupta,a   Aryan Gautam,a   Smaranika Patra,a   Amit Kunwar ORCID logo *bc  and  Pijus K. Sasmal ORCID logo *a  

* Corresponding authors

a School of Physical Sciences, Jawaharlal Nehru University, New Delhi 110067, India
E-mail: pijus@jnu.ac.in, pijussasmal@gmail.com

b Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Anushaktinagar, Mumbai 400085, India
E-mail: kamit@barc.gov.in

c Homi Bhabha National Institute, Anushaktinagar, Mumbai – 400094, India

Abstract

A rationally designed luminescent probe based on cyclometalated iridium(III) AIEgens was developed for the rapid, sensitive, and specific detection of NAD(P)H in aqueous media. This probe was successfully utilized for bioimaging of NADH within the mitochondria of living cancer cells, highlighting its potential as a valuable tool for investigating NADH-associated cellular processes.

Graphical abstract: Harnessing the power of iridium AIEgens for NAD(P)H detection in aqueous medium and living cells

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Article information

DOI
https://doi.org/10.1039/D5CC01124H
Article type
Communication
Submitted
01 Mar 2025
Accepted
15 Apr 2025
First published
22 Apr 2025

Chem. Commun., 2025, Advance Article

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Harnessing the power of iridium AIEgens for NAD(P)H detection in aqueous medium and living cells

A. Gupta, A. Gautam, S. Patra, A. Kunwar and P. K. Sasmal, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC01124H

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