From the journal:

Chemical Communications

Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles†

Chloe Duffield, ORCID logo a   Laura M. Rey Gomez, ORCID logo a   Su Su Thae Hnit, ORCID logo a   Wei Zhang, ORCID logo a   Simon Chang-Hao Tsao,ab   David W. Inglis ORCID logo c  and  Yuling Wang ORCID logo *a  

* Corresponding authors

a School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Australia
E-mail: yuling.wang@mq.edu.au

b Department of Surgery, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia

c School of Engineering, Faculty of Science and Engineering, Macquarie University, Australia

Abstract

Cancer cell-derived small extracellular vesicles (sEVs) are new promising biomarkers for improved cancer diagnosis. A multi-line lateral flow immunoassay (LFIA) has been proposed for sensitive detection and subtyping of breast cancer-derived sEVs. The expression of cancer surface biomarkers (EpCAM) was confirmed through colorimetric analysis of cell line-derived sEVs (p = 0.076) and patient samples, highlighting the potential for their use as a clinical aid.

Graphical abstract: Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles

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Article information

DOI
https://doi.org/10.1039/D5CC01038A
Article type
Communication
Submitted
03 Mar 2025
Accepted
13 May 2025
First published
21 May 2025

Chem. Commun., 2025, Advance Article

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Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles

C. Duffield, L. M. Rey Gomez, S. S. T. Hnit, W. Zhang, S. C. Tsao, D. W. Inglis and Y. Wang, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC01038A

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