Bifunctional nanodisc platforms for studies on self-assembly and amyloid fibrillation

Abstract

Nanodiscs are emerging as valuable tools for studying lipid–protein interactions. In this study, we demonstrate the dual role of nanodiscs in modulating human amylin (hIAPP) fibrillation using NMR and HS-AFM. Peptide-based nanodiscs promote hIAPP fibrillation, while polymer-based nanodiscs inhibit aggregation. These findings broaden the applications of nanodiscs beyond structural studies.