From the journal:

Chemical Communications

A dual-response fluorescent probe Rh-O-QL for simultaneous monitoring of NAD(P)H and pH during mitochondrial autophagy†

Liandi Guan,ab   Wanting Hu,b   Shiyu Zhang,b   Yongjian Aib  and  Qionglin Liang ORCID logo *b  

* Corresponding authors

a Institute of Basalt Fiber in Eco-Application, School of Environmental Science and Engineering, Qingdao University, Qingdao, Shandong, P. R. China

b MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Laboratory of Flexible Electronics Technology, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, P. R. China
E-mail: liangql@tsinghua.edu.cn

Abstract

Mitochondrial autophagy is closely related to abnormal NAD(P)H and pH. Here, we synthesized a dual-response fluorescent probe with high selectivity for NAD(P)H and sensitivity in the physiological pH range, for simultaneous imaging analysis of mitochondrial NAD(P)H and pH, holding potential as a novel tool for understanding mitochondria-associated diseases.

Graphical abstract: A dual-response fluorescent probe Rh-O-QL for simultaneous monitoring of NAD(P)H and pH during mitochondrial autophagy

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Article information

DOI
https://doi.org/10.1039/D5CC00961H
Article type
Communication
Submitted
21 Feb 2025
Accepted
17 Apr 2025
First published
18 Apr 2025

Chem. Commun., 2025, Advance Article

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A dual-response fluorescent probe Rh-O-QL for simultaneous monitoring of NAD(P)H and pH during mitochondrial autophagy

L. Guan, W. Hu, S. Zhang, Y. Ai and Q. Liang, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC00961H

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