Issue 44, 2025
From the journal:

Chemical Communications

A self-assembled fusion hydrophobin-coated nanodiamond system for synergistic targeted therapy of colorectal cancer†

Haotian Li,a   Yupeng Wang,a   Hui Qiao,b   Fengming Liu,a   Zhuoyu Li,a   Zhiqiang Han,c   Zhihua Guo,a   Yingqi Li ORCID logo *bd  and  Mingqiang Qiao ORCID logo *ae  

* Corresponding authors

a Laboratory of Resource Microbiology and Engineering, School of Life Sciences, Shanxi University, Taiyuan 030006, P. R. China
E-mail: qmq@sxu.edu.cn

b Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, P. R. China

c Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, China

d Department of Chemistry, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P. R. China
E-mail: wkyqli@sxu.edu.cn

e The Key Laboratory of Molecular and Microbiology Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, P. R. China

Abstract

A novel nano-platform (GE11-HGFI@ND-DOX) capable of specifically targeting colorectal cancer HCT-116 cells with highly expressed EGFR receptors, exhibiting precise targeting and enhanced therapy, while enhancing its dispersivity and hydrophilicity is reported. This work opens up prospects for the development of synergistic targeted therapy by integrating hydrophobins and nanodiamond encapsulated drug delivery systems.

Graphical abstract: A self-assembled fusion hydrophobin-coated nanodiamond system for synergistic targeted therapy of colorectal cancer

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Article information

DOI
https://doi.org/10.1039/D5CC00919G
Article type
Communication
Submitted
20 Feb 2025
Accepted
16 Apr 2025
First published
26 Apr 2025

Chem. Commun., 2025,61, 8075-8078

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A self-assembled fusion hydrophobin-coated nanodiamond system for synergistic targeted therapy of colorectal cancer

H. Li, Y. Wang, H. Qiao, F. Liu, Z. Li, Z. Han, Z. Guo, Y. Li and M. Qiao, Chem. Commun., 2025, 61, 8075 DOI: 10.1039/D5CC00919G

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