A simple strategy for measuring the genuine resonance Raman optical activity (RROA) of nonpolar molecules

Abstract

Resonance Raman optical activity (RROA) enables increasing very-low analytical sensitivity of ROA, essential for its applications in biomedicine. Since discovery of the ECD-Raman effect, there is discussion if RROA is measurable. Here, we present a straightforward strategy for registration of RROA of nonpolar compounds based on their encapsulation in micelles, enabling nearly complete elimination of the ECD-Raman contribution.