Peptide catalyzed regio- and enantioselective ε-alkylation of γ-branched 2,4-dienals via trienamine activation

Abstract

The regio- and enantioselective ε-alkylation of γ-branched 2,4-dienals was successfully achieved via trienamine catalysis. N-Terminal prolyl pentapeptide with a turn structure was effective as a catalyst for this transformation.