A water-soluble cationic [2]biphenyl-extended pillar[6]arene: synthesis, host–guest interaction with hemin and application in chemodynamic/photodynamic cancer therapy

Yan Cai; Yue Zhang; Xufeng Liang; Chunlin Deng; Jianxia Zhang; Haotian Wang; Hui Duan; Yong Yao

doi:10.1039/D5CC00627A

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A water-soluble cationic [2]biphenyl-extended pillar[6]arene: synthesis, host–guest interaction with hemin and application in chemodynamic/photodynamic cancer therapy†

Yan Cai,‡^a Yue Zhang,‡^a Xufeng Liang,^a Chunlin Deng,^a Jianxia Zhang,^a Haotian Wang,^a Hui Duan^a and Yong Yao

*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu, P. R. China
E-mail: yaoyong1986@ntu.edu.cn

Abstract

A water-soluble cationic [2]biphenyl-extended pillar[6]arene (CBpExP₆) was designed and synthesized successfully. It could form a stable 1 : 1 complex with hemin, thereby enhancing the stability of hemin in water, and can be further applied in cancer CDT and PDT.

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Article information

DOI: https://doi.org/10.1039/D5CC00627A
Article type: Communication
Submitted: 04 Feb 2025
Accepted: 10 Mar 2025
First published: 10 Mar 2025

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Chem. Commun., 2025,61, 5333-5336

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A water-soluble cationic [2]biphenyl-extended pillar[6]arene: synthesis, host–guest interaction with hemin and application in chemodynamic/photodynamic cancer therapy

Y. Cai, Y. Zhang, X. Liang, C. Deng, J. Zhang, H. Wang, H. Duan and Y. Yao, Chem. Commun., 2025, 61, 5333 DOI: 10.1039/D5CC00627A

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Chemical Communications

A water-soluble cationic [2]biphenyl-extended pillar[6]arene: synthesis, host–guest interaction with hemin and application in chemodynamic/photodynamic cancer therapy†

Abstract

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A water-soluble cationic [2]biphenyl-extended pillar[6]arene: synthesis, host–guest interaction with hemin and application in chemodynamic/photodynamic cancer therapy

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