Issue 27, 2025
From the journal:

Chemical Communications

Copper-catalyzed chemoselective C–H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds†

Yuting Zhao,a   Xin Ji, ORCID logo a   Yuanjing Xiao, ORCID logo *a   Xingxing Wu ORCID logo *b  and  Lu Liu ORCID logo *ac  

* Corresponding authors

a School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road Shanghai, P. R. China
E-mail: yjxiao@chem.ecnu.edu.cn, lliu@chem.ecnu.edu.cn

b State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang, P. R. China
E-mail: wuxx@gzu.edu.cn

c School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, P. R. China

Abstract

Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules via a chemoselective C–H functionalization/dearomatization sequence was developed.

Graphical abstract: Copper-catalyzed chemoselective C–H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds

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Article information

DOI
https://doi.org/10.1039/D5CC00594A
Article type
Communication
Submitted
02 Feb 2025
Accepted
04 Mar 2025
First published
05 Mar 2025

Chem. Commun., 2025,61, 5162-5165

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Copper-catalyzed chemoselective C–H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds

Y. Zhao, X. Ji, Y. Xiao, X. Wu and L. Liu, Chem. Commun., 2025, 61, 5162 DOI: 10.1039/D5CC00594A

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