Issue 36, 2025

Electroorganocatalytic asymmetric Diels–Alder cycloaddition of hydroquinones with α,β-unsaturated aldehydes

Abstract

The concept of combining asymmetric aminocatalysis with electrochemistry remains underexplored. Herein, we report an electrochemically driven Diels–Alder cycloaddition reaction of substituted hydroquinones with a series of enals activated by a TMS-protected prolinol catalyst, leading to optically active products with high yields and perfect enantiomeric ratios up to 99 : 1 e.r.

Graphical abstract: Electroorganocatalytic asymmetric Diels–Alder cycloaddition of hydroquinones with α,β-unsaturated aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
27 Jan 2025
Accepted
18 Mar 2025
First published
08 Apr 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025,61, 6655-6658

Electroorganocatalytic asymmetric Diels–Alder cycloaddition of hydroquinones with α,β-unsaturated aldehydes

D. Pomikło, K. Romaniuk, L. Sieroń and A. Albrecht, Chem. Commun., 2025, 61, 6655 DOI: 10.1039/D5CC00505A

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