Synthesis of chiral β-hydroxy allylic sulfides via iridium-catalyzed asymmetric cascade allylation/acyl transfer rearrangement

Abstract

Iridium-catalyzed asymmetric allylation/acyl transfer rearrangement of thioesters and vinyl ethylene carbonate (VEC) has been developed. A wide range of structurally important chiral β-hydroxy allylic sulfide derivatives could be prepared in good yields with excellent enantioselectivity.