Boron appended Ru-NHC catalyzed selective deoxygenative hydrogenation of tertiary amides and desulfurization of thioamides†
Abstract
Herein, we disclosed a selective hydrogenation of tertiary amides and desulfurization of thioamides to amines with phenylsilane as a reductant, using a bifunctional Ru-NHC complex 1 appended with a Lewis acid in the secondary coordination sphere. The catalytic process was further utilized to synthesize biologically relevant amine drug molecules in good yields.