Herein, we disclosed a selective hydrogenation of tertiary amides and desulfurization of thioamides to amines with phenylsilane as a reductant, using a bifunctional Ru-NHC complex 1 appended with a Lewis acid in the secondary coordination sphere. The catalytic process was further utilized to synthesize biologically relevant amine drug molecules in good yields.
R. Sharma, G. Kenguva, R. Dandela and P. Daw, Chem. Commun., 2025, 61, 9460 DOI: 10.1039/D5CC00399G
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