Overcoming kinetic barriers of remote electrochemiluminescence on boron-doped diamond via catalytic coreactant oxidation

Alessandro Fracassa; Chiara Mariani; Andrea Fiorani; Yasuaki Einaga; Conor F. Hogan; Francesco Paolucci; Neso Sojic; Paul S. Francis; Giovanni Valenti

doi:10.1039/D5CC00270B

Overcoming kinetic barriers of remote electrochemiluminescence on boron-doped diamond via catalytic coreactant oxidation†

Alessandro Fracassa,

^a Chiara Mariani,

^a Andrea Fiorani,

^b Yasuaki Einaga,

^b Conor F. Hogan,

^c Francesco Paolucci,

^ad Neso Sojic,

^e Paul S. Francis

*^f and Giovanni Valenti

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum – University of Bologna, Via Gobetti 85, 40129 Bologna, Italy
E-mail: g.valenti@unibo.it

^b Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan

^c The Biomedical and Environmental Sensor Technology (BEST) Research Centre, Biosensors Program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, VIC, Australia

^d ICMATE-CNR, Corso Stati Uniti 4, 35127 Padova, Italy

^e University Bordeaux, CNRS, Bordeaux INP, ISM, UMR 5255, ENSMAC, Pessac, France

^f Centre for Sustainable Bioproducts, Faculty of Science, Engineering and Built Environment, Deakin University, Geelong, Victoria 3220, Australia

Abstract

The effectiveness of boron-doped diamond (BDD) as a platform for electrochemiluminescence (ECL) bead-based bioassays is hindered by the sluggish rate of heterogeneous tri-n-propylamine (TPrA) oxidation. To address this, we investigate the ECL of Ru(II)-coated microbeads in the presence of a redox mediator, exploring the effect of applied potential and electrode surface terminations. Using a redox mediator, the ECL signal on BDD is enhanced by up to 46-fold.

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DOI: https://doi.org/10.1039/D5CC00270B
Article type: Communication
Submitted: 15 Jan 2025
Accepted: 03 Feb 2025
First published: 03 Feb 2025
This article is Open Access

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Chem. Commun., 2025,61, 3900-3903

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Overcoming kinetic barriers of remote electrochemiluminescence on boron-doped diamond via catalytic coreactant oxidation

A. Fracassa, C. Mariani, A. Fiorani, Y. Einaga, C. F. Hogan, F. Paolucci, N. Sojic, P. S. Francis and G. Valenti, Chem. Commun., 2025, 61, 3900 DOI: 10.1039/D5CC00270B

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Chemical Communications

Overcoming kinetic barriers of remote electrochemiluminescence on boron-doped diamond via catalytic coreactant oxidation†

Abstract

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Overcoming kinetic barriers of remote electrochemiluminescence on boron-doped diamond via catalytic coreactant oxidation

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