Difunctional oxidatively cleavable alkenyl boronates: application to cellular peroxide sensing from a fluorophore–quencher pair

Abstract

This manuscript describes the development of difunctional alkenyl boronates that contain an oxidatively releasable cargo and an amine for attaching to groups that can improve physical properties or enhance cellular targeting. The design is applied to a FRET-based system that delivers a selective fluorescence response in oxidatively stressed cells.