Si-stereogenic remote alkenyl monohydrosilanes enabled by CuH-catalyzed enantioselective hydrosilylation of strained methylenecyclopropanes

Abstract

Metal-catalyzed synthesis of Si-stereogenic monohydrosilanes with remote unsaturated groups remains challenging due to the potential self-overfunctionalization. Herein, we report a CuH-catalyzed enantioselective hydrosilylation of strained methylenecyclopropanes, affording various Si-stereogenic remote (E)-alkenyl-substituted monohydrosilanes with high enantioselectivity. The resulting monohydrosilanes are valuable synthons, which was demonstrated by post-transformations of olefin and silane moieties.