Lipid structure-dependent CD1d functional stabilization and immunomodulation of endogenous glucosylceramides

Abstract

Newly developed synthetic methods for monoglycosylceramides enabled representative brain glycolipid synthesis. Immunomodulatory activities of the glycolipids were examined via CD1d and Mincle. CD1d strongly bound endogenous GlcCer with longer unsaturated fatty acids (e.g., C24:1), partly inhibiting other antigens and stabilizing CD1d's immunological role in presenting lipid antigens to NKT cells.