Photocatalytic and straightforward olefination of alkyl aldehydes with alkynylphosphonates enabled by Cu(i)-photosensitizers

Abstract

A visible light-driven photocatalytic olefination of alkyl aldehydes into vinylphosphonates directly with alkynylphosphonates has been successfully developed with high E-selectivity through a P/N-heteroleptic Cu(I)-photosensitizer-enabled, secondary amine-aided tandem radical process comprising in situ generation of an alkyl-substituted α-amino radical, addition of the α-amino radical across alkynylphosphonates, 1,5-HAT, C–N bond cleavage and 1,3-allylic isomerization.