Photodynamic ROS inducers delivered via electrostatic antibody targeted (ELART) nanocarriers incorporate into tumour cells and inhibit colony growth

Andreas Faust; Andrew F. Berdel; Evelyn Bruns; Nicole Bäumer; Timo Krassuski; Lisa Wittmann; Linnea Franke; Iván Maisuls; Stephan Niland; Johannes A. Eble; Cristian A. Strassert; Georg Lenz; Wolfgang E. Berdel; Sebastian Bäumer

doi:10.1039/D4CC06569G

Photodynamic ROS inducers delivered via electrostatic antibody targeted (ELART) nanocarriers incorporate into tumour cells and inhibit colony growth†

Andreas Faust,

‡^a Andrew F. Berdel,

‡^b Evelyn Bruns,‡^b Nicole Bäumer,^b Timo Krassuski,

^b Lisa Wittmann,^b Linnea Franke,^b Iván Maisuls,^cd Stephan Niland,

^e Johannes A. Eble,

^e Cristian A. Strassert,^cd Georg Lenz,^b Wolfgang E. Berdel^b and Sebastian Bäumer^b

Author affiliations

^a European Institute for Molecular Imaging (EIMI), University of Münster, Röntgenstraße 16, Münster, Germany
E-mail: faustan@uni-muenster.de

^b Department of Medicine A, Hematology/Oncology, University Hospital Münster, Albert-Schweitzer Campus 1, Münster, Germany
E-mail: baumers@uni-muenster.de

^c Institut fuer Anorganische und Analytische Chemie, Universität Munster, Corrensstraße 28/30, 48149 Münster, Germany

^d CiMIC, SoN, CeNTech, Universität Münster, Heisenbergstraße 11, 48149 Münster, Germany

^e Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstraße 15, 48149 Münster, Germany

Abstract

We designed and synthesised an anionic small-molecular photosensitizer (aPSM-Cy3.5) for incorporation into electrostatic antibody targeted (ELART) vesicles, consisting of a protamine-coupled antibody as targeting unit, free protamine and aPSM-Cy3.5. These nanocarriers specifically internalize into different solid tumour cell lines. Upon illumination, the aPSM component initiates the production of reactive oxygen species (ROS). Tumour cells from lung, colorectal and pancreatic cancer with internalized aPSM show decreased growth in colony forming assay. This supports the development of systemically applicable anionic ROS inducers capable of specifically targeting tumour cells.

Chemical Communications

Photodynamic ROS inducers delivered via electrostatic antibody targeted (ELART) nanocarriers incorporate into tumour cells and inhibit colony growth†

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Photodynamic ROS inducers delivered via electrostatic antibody targeted (ELART) nanocarriers incorporate into tumour cells and inhibit colony growth

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