Issue 16, 2025
From the journal:

Chemical Communications

Glycosylated and rhodamine-conjugated tetraphenylethylene: a type I and II reactive oxygen species generator for photodynamic therapy†

Jia-wei Zhang,a   Gai-li Feng,a   Xin Niu,a   Yi-chen Liu,a   Wei Zhou,a   Qing-yu Ma,a   Guang-jian Liu, ORCID logo a   Yuan Zhang*ab  and  Guo-wen Xing ORCID logo *a  

* Corresponding authors

a College of Chemistry, Beijing Normal University, Beijing, China
E-mail: yuanzhang@bnu.edu.cn, gwxing@bnu.edu.cn

b Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing, China

Abstract

A lactosylated and AIE-active multifunctional photosensitizer (Lac-TR) was synthesized. Lac-TR can self-assemble into fluorescent nanoparticles (Lac-TRs) to achieve fluorescence self-reporting during photodynamic therapy and induce pyroptosis under both normoxia and hypoxia to kill HepG2 cells.

Graphical abstract: Glycosylated and rhodamine-conjugated tetraphenylethylene: a type I and II reactive oxygen species generator for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D4CC06509C
Article type
Communication
Submitted
12 Dec 2024
Accepted
21 Jan 2025
First published
21 Jan 2025

Chem. Commun., 2025,61, 3403-3406

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Glycosylated and rhodamine-conjugated tetraphenylethylene: a type I and II reactive oxygen species generator for photodynamic therapy

J. Zhang, G. Feng, X. Niu, Y. Liu, W. Zhou, Q. Ma, G. Liu, Y. Zhang and G. Xing, Chem. Commun., 2025, 61, 3403 DOI: 10.1039/D4CC06509C

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