Design of a modular, palladium-catalyzed carbonylative synthesis of pyrido[2,1-α]isoindoles via benzyne 1,3-dipolar cycloaddition

Abstract

We report a palladium catalyzed, multicomponent synthesis of pyrido[2,1-α]isoindoles via carbonylative coupling of imines and 2-bromopyridines to form mesoionic dipoles, followed by cycloaddition with in situ generated arynes. This one-pot method allows efficient, modular assembly of polysubstituted products with independent control of each building block.