Issue 15, 2025

Development of ROS-triggered masked liposomes for activated cellular delivery using a charge balance strategy

Abstract

We report a charge balance strategy for reactive oxygen species (ROS)-triggered activation of liposome cell delivery by unmasking cationic membranes. Zeta potential experiments, microplate-based vesicle interaction assays, and cellular delivery studies confirmed that modification of anionic lipid 1 by ROS led to the uncaging of cationic liposomes, thereby driving cellular association.

Graphical abstract: Development of ROS-triggered masked liposomes for activated cellular delivery using a charge balance strategy

Supplementary files

Article information

Article type
Communication
Submitted
27 Nov 2024
Accepted
09 Dec 2024
First published
10 Dec 2024

Chem. Commun., 2025,61, 3131-3134

Development of ROS-triggered masked liposomes for activated cellular delivery using a charge balance strategy

M. B. Mustafa, J. Lou, M. A. Phillips, R. F. Turner, J. A. Baccile and M. D. Best, Chem. Commun., 2025, 61, 3131 DOI: 10.1039/D4CC06309K

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