A protein trans-splicing (PTS)-based method for screening the peptides capable of binding to a target protein was developed using an engineered split intein and an aminoglycoside phosphotransferase. Two peptides selected against MDM2 bind to MDM2 with high affinity and a peptide can induce apoptosis in SJSA-1 cells.
Y. Watanabe, C. Tezuka, K. Nobusawa and T. Takahashi, Chem. Commun., 2025, 61, 6332 DOI: 10.1039/D4CC06138A
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