Issue 16, 2025
From the journal:

Chemical Communications

ROS-responsive poly(β-amino ester) nanoparticles enable targeted delivery of mRNA vaccine to splenic antigen-presenting cells†

Meng Jiang,‡ade   Lingjian Yan,‡ac   Ling Zeng,‡ade   Yingseng Tang,ade   Zixi Zhang,ade   Baihua Chen,ade   Min Qiu*b  and  Jinjin Chen ORCID logo *ade  

* Corresponding authors

a Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China
E-mail: chenjj365@mail.sysu.edu.cn

b Human Phenome Institute, Fudan University, Shanghai 201203, P. R. China
E-mail: mqiu@fudan.edu.cn

c Department of Stomatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, P. R. China

d Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China

e ChinaNanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan 528200, P. R. China

Abstract

Intravenous mRNA vaccines show promise for stimulating immune cells but face challenges in targeting APCs due to high liver accumulation. To address this, we developed ROS-responsive PBAE nanoparticles, 93-TKA10-19, designed to target splenic APCs, enhance mRNA expression, and induce a Th1-skewed immune response, advancing mRNA vaccine efficacy.

Graphical abstract: ROS-responsive poly(β-amino ester) nanoparticles enable targeted delivery of mRNA vaccine to splenic antigen-presenting cells

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Article information

DOI
https://doi.org/10.1039/D4CC06064D
Article type
Communication
Submitted
14 Nov 2024
Accepted
27 Jan 2025
First published
27 Jan 2025

Chem. Commun., 2025,61, 3371-3374

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ROS-responsive poly(β-amino ester) nanoparticles enable targeted delivery of mRNA vaccine to splenic antigen-presenting cells

M. Jiang, L. Yan, L. Zeng, Y. Tang, Z. Zhang, B. Chen, M. Qiu and J. Chen, Chem. Commun., 2025, 61, 3371 DOI: 10.1039/D4CC06064D

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