Issue 8, 2025

Photoredox radical/polar crossover enables carbo-heterofunctionalization of alkenes: facile access to 1,3-difunctionalized nitro compounds

Abstract

Herein, we present an efficient and practical method for multicomponent carbo-heterofunctionalization of alkenes via radical-polar crossover photoredox catalysis. Employing geminal bromonitroalkanes as redox-active reagents with a wide range of O-centered nucleophiles allows rapid access to various 1,3-difunctionalized nitro compounds, including β-nitro ketones, 1,3-nitro alcohols, 1,3-nitro ethers as well as cyclic molecules.

Graphical abstract: Photoredox radical/polar crossover enables carbo-heterofunctionalization of alkenes: facile access to 1,3-difunctionalized nitro compounds

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
11 Nov 2024
Accepted
19 Dec 2024
First published
20 Dec 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025,61, 1689-1692

Photoredox radical/polar crossover enables carbo-heterofunctionalization of alkenes: facile access to 1,3-difunctionalized nitro compounds

S. Patra, V. Valsamidou, B. N. Nandasana and D. Katayev, Chem. Commun., 2025, 61, 1689 DOI: 10.1039/D4CC06005A

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