BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc

Valeska Viereckt; Frank Abendroth; Alexander Schauerte; Marina Gerhard; Crispin Lichtenberg; Dmitri Kosenkov; Olalla Vázquez

doi:10.1039/D4CC05979D

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc†

Valeska Viereckt,

^a Frank Abendroth,

^a Alexander Schauerte,

^b Marina Gerhard,

^b Crispin Lichtenberg,^a Dmitri Kosenkov

^cd and Olalla Vázquez

*^ae

Author affiliations

* Corresponding authors

^a Department of Chemistry, Marburg University, Marburg, Germany
E-mail: olalla.vazquez@staff.uni-marburg.de

^b Department of Physics and Materials Science Center, Marburg University, Marburg, Germany

^c Princeton Precision Health (PPH), Princeton University, Princeton, USA

^d Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, USA

^e Centre for Synthetic Microbiology (SYNMIKRO), University of Marburg, Marburg, Germany

Abstract

We report how the conjugation of coelenterazine (CTZ) to BODIPY retains its activity as a versatile substrate for luciferase-type enzymes opening the possibility of taking advantage of BODIPY's fluorescent properties and capacity to generate singlet oxygen. Bioluminescence imaging-guided photodynamic therapy or ¹O₂-triggered drug release are potential applications of these conjugates.

This article is part of the themed collection: ChemComm 60th Anniversary Collection

Download options Please wait...

Supplementary files

Supplementary information PDF (14475K)

Article information

DOI: https://doi.org/10.1039/D4CC05979D
Article type: Communication
Submitted: 09 Nov 2024
Accepted: 03 Mar 2025
First published: 03 Mar 2025
This article is Open Access

Download Citation

Chem. Commun., 2025,61, 5190-5193

Permissions

Request permissions

BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc

V. Viereckt, F. Abendroth, A. Schauerte, M. Gerhard, C. Lichtenberg, D. Kosenkov and O. Vázquez, Chem. Commun., 2025, 61, 5190 DOI: 10.1039/D4CC05979D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc†

Abstract

Supplementary files

Article information

Download Citation

Permissions

BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc

Social activity

Search articles by author

Spotlight

Advertisements