Design and synthesis of a clickable cell-permeable pseudopeptide Pin1 inhibitor with antiproliferative effects on human multiple myeloma cell line

Abstract

The synthesis of a library of minimal-backbone, cell-permeable, clickable pseudopeptide Pin1 ligands with potential applications in drug development and biochemical studies is reported. The ligands’ affinity constants were evaluated using NMR. The lead compound 4b, demonstrated effective cell permeability, inhibitory activity, and an antiproliferative effect on a multiple myeloma cell line.