Issue 8, 2025

Photoinduced synthesis of trisubstituted allylic molecules via migratory allylation of olefins

Abstract

A transition-metal-free method to afford diverse trisubstituted allylic molecules via migratory allylation of olefins under light irradiation is described. This system tolerated diverse N-tosylhydrazones and olefinic boronic acids. Successful allylation of drugs and natural-product analogues was achieved. The gram-scale synthesis and subsequent post-transformation demonstrated the potential applications of this strategy.

Graphical abstract: Photoinduced synthesis of trisubstituted allylic molecules via migratory allylation of olefins

Supplementary files

Article information

Article type
Communication
Submitted
11 Oct 2024
Accepted
17 Dec 2024
First published
18 Dec 2024

Chem. Commun., 2025,61, 1653-1656

Photoinduced synthesis of trisubstituted allylic molecules via migratory allylation of olefins

D. Xia, N. Zhang, M. Zhong, W. Wang, Q. Li, Y. Zhang and W. Zhang, Chem. Commun., 2025, 61, 1653 DOI: 10.1039/D4CC05368K

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